Generally, COPD results in progressive worsening of QOL over time. Factors such as dyspnea, depression, anxiety, and exercise tolerance have been reported to be better correlated with health status than the widely-used spirometric values. Health-related quality of life (QOL) is being recognized as an important outcome when evaluating patients with chronic obstructive pulmonary disease (COPD). Keywords: annual change, forced expiratory volume in 1 second, SGRQ, smoking, exacerbation The activity component of SGRQ generally deteriorated over years, while the symptom component rather improved in some patients with COPD under appropriate treatment. For the symptom component, a history of exacerbation by admission definition was the determinant of its deterioration, whereas use of beta agonists was related to improvement.Ĭonclusion: The longitudinal changes of quality of life and their determinants are markedly different and independent between its components. Continuous smoking was another factor for worsening of the activity component. Of the follow-up data, ∆FEV 1/year was the best predictor for worsening of the components of SGRQ. Larger reversibility was related to symptom component improvement. Of the baseline data, predictors for worsening of the activity component were older age and lower body mass index. Results: The activity component of SGRQ generally deteriorated over time, and its annual decline was the greatest in the rapid decliners (75 percentile), and it did not deteriorate even in the rapid decliners. The subjects were classified into the rapid decliners, slow decliners, and sustainers based on ∆FEV 1/year. The longitudinal changes in St George’s Respiratory Questionnaire (SGRQ) scores were annually evaluated with forced expiratory volume in 1 second (FEV 1). Methods: In the Hokkaido COPD Cohort Study, 261 subjects were appropriately treated and followed over 5 years with a 74% follow-up rate at the end. On behalf of the Hokkaido COPD Cohort Study InvestigatorsġFirst Department of Medicine, Hokkaido University School of Medicine, 2Department of Biostatistics, Hokkaido University Graduate School of Medicine, Sapporo, Japanīackground: The aim of the study was to examine the longitudinal change in quality of life components of patients with chronic obstructive pulmonary disease (COPD). Katsura Nagai, 1 Hironi Makita, 1 Masaru Suzuki, 1 Kaoruko Shimizu, 1 Satoshi Konno, 1 Yoichi M Ito, 2 Masaharu Nishimura 1

Rika nishimura six years